Context-aware mobile app for the multidimensional assessment of the elderly,

Rural areas in Europe are presenting a decreasing population density and an increasing age index. These elders usually present multiple diseases that require complex tools to identify the exact cares that they need. Currently, different frameworks can evaluate their functional status and identify the required cares to maintain their Quality of Life, together with the associated cost to the health system. Nevertheless, these frameworks are usually questionnaires that have to be performed by already overloaded professionals. In this paper, we make use of mobile technologies to build a system capable of monitoring the activities of the elderly and analysing these data to assess their functional status. The experiments carried out show us that it correctly evaluates these patients and reduces the effort required by health professionals

Enriched elderly virtual profiles by means of a multidimensional integrated assessment platform

The pressure over Healthcare systems is increasing in most developed countries. The generalized aging of the population is one of the main causes. This situation is even worse in underdeveloped, sparsely populated regions like Extremadura in Spain or Alentejo in Portugal. The authors propose to use the Situational-Context, a technique to seamlessly adapt Internet of Things systems to the needs and preferences of their users, for virtually modeling the elderly. These models could be used to enhance the elderly experience when using those kind of systems without raising the need for technical skills or the costs of implementing such systems by the regional healthcare systems. In this paper, the integration of a multidimensional integrated assessment platform with such virtual profiles is presented. The assessment platform provides and additional source of information for the virtual profiles that is used to better adapt existing systems to the elders needs

Contributions to the ontology of aging, the sensitive indicators of rehabilitation nursing care, in terms of self-care, in people with respiratory disorders

With the increase in the average life expectancy, the appearance of chronic diseases and, in particular, in the respiratory forum and its disadvantages in the autonomy and self-care of patients, brought an important paradigm for health care and, in particular, rehabilitation nursing, with implications for the development of ontologies of aging. Thus, it is imperative to systematize them in scientifically measurable indicators to demonstrate the benefit that rehabilitation nursing brings to improve patients' quality of life, thus ensuring excellence. Each area of scientific health should contribute to the construction of aging ontology. Objective: to identify indicators sensitive to nursing care of rehabilitation, in terms of self-care, in relation to those with respiratory pathology, to be integrated into the ontology of aging. Methods: A systematic review of the literature was performed using the EBSCO (full-text MEDLINE, CINAHL, Full-Text Plus, British Nursing Index), using the PI [C] O method with 6 emergent articles. Results: A total of 20 indicators were identified, including: Ability to perform activities, increase physical and functional independence, symptom management, reduction of complications, increase in quality of life, which can be allocated as a proposal for classes of the aging ontology. Conclusion: Knowledge of indicators sensitive to nursing care recognition of the importance of rehabilitation nursing in increasing self-care and autonomy for people with respiratory pathology, and research in this area is fundamental for its effectiveness and efficiency, and its integration in the ontologies of aging is fundamental

Arquitectura Inteligente CPPS Integrada en el Uso de la Norma IEC-61499, con Bloque de Funciones Altamente Adaptables en la Industria 4.0

Today, we are experiencing what it is being labelled as the Fourth Industrial Revolution (Industry 4.0) in terms of automation and control systems of cyber - physical production environments. These systems not only allow access to many innovative features based on network connections, but they also provide access to the world of the Internet of Things (IoT).  It is in this context that IoT changes the ways to link new technologies in order to obtain more efficient, intelligent, flexible and adaptable production systems; thus becoming an interdependence of the product itself that the companies wish to commercialize. Cyber- Physical Production Systems (CPPS) have the advantages of granular communications, common electric bandwidth for all users regardless of data speeds, compatibility in connection with free or guided space communication links and with the major compatibility with intensity modulation. IEC 61499 is generally based on a generic architecture, with specific software requirements, development rules that allow for portability and device configuration.Keywords: IoT, configuration, communication, CPPS, Industry 4.0, smart

A proposal of sensitive indicators of the rehabilitation nursing care of people in the surgical process, to be included in the ontology of aging

Given the complex surgical scenario observed today, it is necessary to change the urgent definition of a specific ontology, especially in terms of aging. The interventions of the Specialist Nurse in Rehabilitation Nursing to the person in the surgical process are primordial for the maintenance of the functional capacities, prevention of complications and impediment of incapacities. However, it is necessary to provide individualized and fostered care in a practice of excellence, and the consequent organized reading of records of an aging ontology for decision making on rehabilitation indicators. Method: a systematic review of the literature was carried out using the EBSCO host (MEDLINE with Full Text, CINAHL Plus with Full Text and MedicLatina), using the PI [C] O method, and 11 articles were selected. Results: 41 indicators were identified to be included in the ontology classes of aging: pain control, patient and family education, support and communication, reduction of postoperative complications, gain of functionality, restoration of physical function, mobility, multidisciplinary intervention and the frequency of interventions. Conclusion: it is considered that it was imperative to identify sensitive indicators for rehabilitation nursing care, based on scientific evidence and thus provide an opportunity for nurses to reflect on their daily practices and conduct their actions towards excellence in care, to propose a set of 41 classes internationally on the ontology of aging

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. Analysis of patient samples reveals increased levels of FZD8 in cancer, correlating with Wnt-11. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription. FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-β/Smad-dependent signaling. Mechanistically, FZD8 forms a TGF-β-regulated complex with TGF-β receptors that is mediated by the extracellular domains of FZD8 and TGFBR1. Targeting FZD8 may therefore inhibit aberrant activation of both Wnt and TGF-β signals in prostate cancer

Exploring DCO+^+ as a tracer of thermal inversion in the disk around the Herbig Ae star HD163296

We aim to reproduce the DCO$^+$ emission in the disk around HD163296 using a simple 2D chemical model for the formation of DCO$^+$ through the cold deuteration channel and a parametric treatment of the warm deuteration channel. We use data from ALMA in band 6 to obtain a resolved spectral imaging data cube of the DCO$^+$ $J$=3--2 line in HD163296 with a synthesized beam of 0."53$\times$ 0."42. We adopt a physical structure of the disk from the literature that reproduces the spectral energy distribution. We then apply a simplified chemical network for the formation of DCO$^+$ that uses the physical structure of the disk as parameters along with a CO abundance profile, a constant HD abundance and a constant ionization rate. Finally, from the resulting DCO$^+$ abundances, we calculate the non-LTE emission using the 3D radiative transfer code LIME. The observed DCO$^+$ emission is reproduced by a model with cold deuteration producing abundances up to $1.6\times 10^{-11}$. Warm deuteration, at a constant abundance of $3.2\times 10^{-12}$, becomes fully effective below 32 K and tapers off at higher temperatures, reproducing the lack of DCO$^+$ inside 90 AU. Throughout the DCO$^+$ emitting zone a CO abundance of $2\times 10^{-7}$ is found, with $\sim$99\% of it frozen out below 19 K. At radii where both cold and warm deuteration are active, warm deuteration contributes up to 20\% of DCO$^+$, consistent with detailed chemical models. The decrease of DCO$^+$ at large radii is attributed to a temperature inversion at 250 AU, which raises temperatures above values where cold deuteration operates. Increased photodesorption may also limit the radial extent of DCO$^+$. The corresponding return of the DCO$^+$ layer to the midplane, together with a radially increasing ionization fraction, reproduces the local DCO$^+$ emission maximum at $\sim$260 AU.Comment: 9 pages, 5 figures, accepted 7th July 201

Sharp values for the constants in the polynomial Bohnenblust-Hille inequality

In this paper we prove that the complex polynomial Bohnenblust-Hille constant for $2$-homogeneous polynomials in ${\mathbb C}^2$ is exactly $\sqrt[4]{\frac{3}{2}}$. We also give the exact value of the real polynomial Bohnenblust-Hille constant for $2$-homogeneous polynomials in ${\mathbb R}^2$. Finally, we provide lower estimates for the real polynomial Bohnenblust-Hille constant for polynomials in ${\mathbb R}^2$ of higher degrees.Comment: 16 page